Blar i forfatter "Heyman, Mats"

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    • DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia 

      Borssén, Magnus; Nordlund, Jessica; Haider, Zahra; Landfors, Mattias; Larsson, Pär; Kanerva, Jukka; Schmiegelow, Kjeld; Flægstad, Trond; Jónsson, Ólafur Gísli; Frost, Britt-Marie; Palle, Josefine; Forestier, Erik; Heyman, Mats; Hultdin, Magnus; Lönnerholm, Gudmar; Degerman, Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-05)
      <p><i>Background</i>: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL ...

    • Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia 

      Nordlund, Jessica; Bäcklin, Christopher L.; Wahlberg, Per; Busche, Stephan; Berglund, Eva C.; Eloranta, Maija-Leena; Flægstad, Trond; Forestier, Erik; Frost, Britt-Marie; Harila-Saari, Arja; Heyman, Mats; Jonsson, Olafur G.; Larsson, Rolf; Palle, Josefine; Rönnblom, Lars; Schmiegelow, Kjeld; Sinnett, Daniel; Söderhäll, Stefan; Pastinen, Tomi; Gustafsson, Mats G.; Lönnerholm, Gudmar; Syvänen, Ann-Christine (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-09-24)
      Background: Although aberrant DNA methylation has been observed previously in acute lymphoblastic leukemia (ALL), the patterns of differential methylation have not been comprehensively determined in all subtypes of ALL on a genome-wide scale. The relationship between DNA methylation, cytogenetic background, drug resistance and relapse in ALL is poorly understood.<p> <p>Results: We surveyed the ...

    • An integrated transcriptome analysis in T-cell acute lymphoblastic leukemia links DNA methylation subgroups to dysregulated TAL1 and ANTP homeobox gene expression 

      Haider, Zahra; larsson, Pär; Landfors, Mattias; Kohn, Linda; Schmiegelow, Kjeld; Flægstad, Trond; Kanerva, Jukka; Heyman, Mats; Hultdin, Magnus; Degerman, Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-21)
      Classification of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients into CIMP (CpG Island Methylator Phenotype) subgroups has the potential to improve current risk stratification. To investigate the biology behind these CIMP subgroups, diagnostic samples from Nordic pediatric T-ALL patients were characterized by genome-wide methylation arrays, followed by targeted exome sequencing, ...

    • Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia 

      Krali, Olga; Marincevic-Zuniga, Yanara; Arvidsson, Gustav; Enblad, Anna Pia; Lundmark, Anders; Sayyab, Shumaila; Zachariadis, Vasilios; Heinäniemi, Merja; Suhonen, Janne; Oksa, Laura; Vepsäläinen, Kaisa; Öfverholm, Ingegerd; Barbany, Gisela; Nordgren, Ann; Lilljebjörn, Henrik; Fioretos, Thoas; Madsen, Hans O.; Marquart, Hanne Vibeke; Flægstad, Trond; Forestier, Erik; Jónsson, Ólafur G.; Kanerva, Jukka; Lohi, Olli; Norén-Nyström, Ulrika; Schmiegelow, Kjeld; Harila, Arja; Heyman, Mats; Lönnerholm, Gudmar; Syvänen, Ann-Christine; Nordlund, Jessica (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-08)
      Genomic analyses have redefined the molecular subgrouping of pediatric acute lymphoblastic leukemia (ALL). Molecular subgroups guide risk-stratification and targeted therapies, but outcomes of recently identified subtypes are often unclear, owing to limited cases with comprehensive profiling and cross-protocol studies. We developed a machine learning tool (ALLIUM) for the molecular subclassification ...